Study of the efficacy of MYCOSTOP for local therapy of dermatomycosis in animals
Abstract
This article presents a study of the effectiveness of the preparation MYCOSTOP (LLC “SPE “SUZIRYA”, Kharkov, Ukraine) in the treatment of dermatomycoses in animals with spontaneous infection. As a fungicidal drug used the preparation terbinafine in oral form (tablets), and for local treatment used the preparation MYCOSTOP (LLC “SPE “SUZIRYA”, Ukraine). Terbinafine was administered in a standard dosage of 20–30 mg/kg once daily (n = 5, 3 cats and 2 dogs). MYCOSTOP was used according to the scheme recommended by the manufacturer and applied to the affected areas of the skin once a day. The treatment regimen was identical in all animals. The criteria of clinical efficacy were the results of the examination with fixation of the dynamics of changes in skin lesions, reduction of pruritus (using a standard 10-point scale), erythema, peeling, the presence of hair growth and a negative mycological study using DERMAKIT. The size of the cells decreased to 0.50 ± 0.63 cm on average, while in 100 % of animals pathological changes (peeling, crusting, erythema, scabs, hyperpigmentation) were not detected at all by the 30th day of the study, and focal alopecia was in the overgrowth stage in 60 % of animals, and in 40 % the skin surface had no pathological changes. Improvements in the clinical condition of the animals were observed from the ninth to the 18th day of the trial (on average 11.2 ± 3.16 days); the overall therapeutic efficacy on the 30th day was 100 %. According to the DERMAKIT specialized medium, the circulation of dermatomycoses in dermatomycoses was determined using the DERMAKIT specialized medium: in dogs Microsporum canis (50 %) and Tricophyton mentagrophytes (50 %), in cats Microsporum canis (50 %), Microsporum gypseum (33 %) and Tricophyton mentagrophytes (17 %), Tricophyton mentagrophytes was detected in two ants. The test results showed the high effectiveness of the combined treatment regimen using as a local fungicide – the preparation MYCOSTOP in spontaneous infection of animals.
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