Communications Biology (Aug 2021)
Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
- Swetha Rajasekaran,
- Jalal Siddiqui,
- Jessica Rakijas,
- Brandon Nicolay,
- Chenyu Lin,
- Eshan Khan,
- Rahi Patel,
- Robert Morris,
- Emanuel Wyler,
- Myriam Boukhali,
- Jayashree Balasubramanyam,
- R. Ranjith Kumar,
- Capucine Van Rechem,
- Christine Vogel,
- Sailaja V. Elchuri,
- Markus Landthaler,
- Benedikt Obermayer,
- Wilhelm Haas,
- Nicholas Dyson,
- Wayne Miles
Affiliations
- Swetha Rajasekaran
- Department of Cancer Biology and Genetics, The Ohio State University
- Jalal Siddiqui
- Department of Cancer Biology and Genetics, The Ohio State University
- Jessica Rakijas
- Department of Cancer Biology and Genetics, The Ohio State University
- Brandon Nicolay
- Massachusetts General Hospital Cancer Center
- Chenyu Lin
- Department of Cancer Biology and Genetics, The Ohio State University
- Eshan Khan
- Department of Cancer Biology and Genetics, The Ohio State University
- Rahi Patel
- Department of Cancer Biology and Genetics, The Ohio State University
- Robert Morris
- Massachusetts General Hospital Cancer Center
- Emanuel Wyler
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
- Myriam Boukhali
- Massachusetts General Hospital Cancer Center
- Jayashree Balasubramanyam
- Department of Nanobiotechnology, Vision Research Foundation, Sankara Nethralaya
- R. Ranjith Kumar
- Department of Nanobiotechnology, Vision Research Foundation, Sankara Nethralaya
- Capucine Van Rechem
- Department of Pathology, Stanford University
- Christine Vogel
- Center for Genomics and Systems Biology, Department of Biology, New York University
- Sailaja V. Elchuri
- Department of Nanobiotechnology, Vision Research Foundation, Sankara Nethralaya
- Markus Landthaler
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
- Benedikt Obermayer
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
- Wilhelm Haas
- Massachusetts General Hospital Cancer Center
- Nicholas Dyson
- Massachusetts General Hospital Cancer Center
- Wayne Miles
- Department of Cancer Biology and Genetics, The Ohio State University
- DOI
- https://doi.org/10.1038/s42003-021-02495-2
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Swetha Rajasekaran et al. integrate transcriptional, proteomic, and metabolomic data to explore how cells adapt to inactivation of RB1, a hallmark of cancer. Combined with their genetic analyses in a Drosophila model, the authors identify key metabolic pathways that may be involved in the growth of RB1-depleted cancer cells.
