Nature Communications (Jun 2020)
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
- Alysha G. Elliott,
- Johnny X. Huang,
- Søren Neve,
- Johannes Zuegg,
- Ingrid A. Edwards,
- Amy K. Cain,
- Christine J. Boinett,
- Lars Barquist,
- Carina Vingsbo Lundberg,
- Jason Steen,
- Mark S. Butler,
- Mehdi Mobli,
- Kaela M. Porter,
- Mark A. T. Blaskovich,
- Sergio Lociuro,
- Magnus Strandh,
- Matthew A. Cooper
Affiliations
- Alysha G. Elliott
- Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland
- Johnny X. Huang
- Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland
- Søren Neve
- Orphazyme
- Johannes Zuegg
- Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland
- Ingrid A. Edwards
- Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland
- Amy K. Cain
- Wellcome Sanger Institute
- Christine J. Boinett
- Wellcome Sanger Institute
- Lars Barquist
- Helmholtz Institute for RNA-based Infection Research (HIRI)
- Carina Vingsbo Lundberg
- Statens Serum Institut
- Jason Steen
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Mark S. Butler
- Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland
- Mehdi Mobli
- Centre for Advanced Imaging, The University of Queensland
- Kaela M. Porter
- Adenium Biotech ApS
- Mark A. T. Blaskovich
- Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland
- Sergio Lociuro
- BioVersys AG
- Magnus Strandh
- Adenium Biotech ApS
- Matthew A. Cooper
- Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-020-16950-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.
