Fermentative Production of 1,3;1,6-β-D-Glucan (Translam), a Labeled Immunostimulant and Investigation of Its Pharmacokinetics and Pharmacodynamics

Abstract

Production of labeled translam from a marine mollusk was provided by the use 1,3-β-D-glucanase. The pharmacokinetics of the14C-translam metabolism in the experimental rats by the accumulation level and the retention time in the organs and tissue and the excretion rate with the feces and urine was of the same character as that of carbohydrates and in particular that of glucose, whereas the excretion of translam mainly with the urine was likely evident of its incomplete hydrolysis after the intramuscular administration.

Keywords

• immunostimulant
• labeled translam
• pharmacokinetics