Nature Communications (Aug 2018)

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

  • Lucy C. Walters,
  • Karl Harlos,
  • Simon Brackenridge,
  • Daniel Rozbesky,
  • Jordan R. Barrett,
  • Vitul Jain,
  • Thomas S. Walter,
  • Chris A. O’Callaghan,
  • Persephone Borrow,
  • Mireille Toebes,
  • Scott G. Hansen,
  • Jonah B Sacha,
  • Shaheed Abdulhaqq,
  • Justin M. Greene,
  • Klaus Früh,
  • Emily Marshall,
  • Louis J. Picker,
  • E. Yvonne Jones,
  • Andrew J. McMichael,
  • Geraldine M. Gillespie

Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13


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Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8+ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding conformations, the positional impact of residues involved and discuss implications for functional presentation to CD8+ T cells.