Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model

Abstract

Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P<0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r=-0.72) and MRS-based fat fraction and FL (r=-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.