Pharmacogenomics and Personalized Medicine (Aug 2020)

CHRM3 rs2165870 Polymorphism Correlates with Postoperative Nausea and Vomiting Incidence and the Efficacy of Ondansetron in a Chinese Han Population

  • Wang J,
  • Li Y,
  • Zheng C,
  • Sun Y,
  • Yang J

Journal volume & issue
Vol. Volume 13
pp. 319 – 326

Abstract

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Jiayu Wang,1,2 Yang Li,3 Cuijuan Zheng,2 Yan Sun,1 Jianping Yang1 1Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, People’s Republic of China; 2Department of Anesthesiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, Jiangsu, People’s Republic of China; 3Jiangsu College of Nursing, Huaian 223300, Jiangsu, People’s Republic of ChinaCorrespondence: Jianping Yang Email [email protected]: Previous GWAS studies have shown that there is a relationship between M3 muscarinic acetylcholine receptor (CHRM3) rs2165870 polymorphism and postoperative nausea and vomiting (PONV) incidence. However, no Chinese studies have addressed this issue.Methods: To explore the relationship between CHRM3 rs2165870 polymorphism and PONV incidence in a Chinese Han population, we enrolled 512 patients receiving elective surgery in this study. CHRM3 rs2165870 polymorphism was genotyped using PCR-RFLP method.Results: We found that AA genotype or A allele of CHRM3 rs2165870 polymorphism elevated the risk of PONV (AA versus GG; OR, 2.88; 95% CI, 1.51– 5.47; P = 0.001; A versus G; OR, 1.39; 95% CI, 1.07– 1.81; P = 0.013). In addition, CHRM3 rs2165870 polymorphism was related to the risk of PONV among the males, smokers, and those individuals with Apfel Score 3– 4 or ASA classification 2– 3. Last, we assessed the effects of CHRM3 rs2165870 polymorphism on the treatment efficacy of ondansetron for PONV. Data uncovered that 103 of 209 patients (49.3%) showed response to ondansetron treatment for PONV. The PONV incidence was significantly higher in AA genotype carriers compared with GG genotype carriers during the first 2 h after surgery, but not from 2 to 24 h after surgery.Conclusion: To sum up, this study reveals that CHRM3 rs2165870 polymorphism is related to the incidence of PONV and treatment effects of ondansetron for preventing PONV in this Chinese Han population.Keywords: postoperative nausea and vomiting, CHRM3, single nucleotide polymorphism, ondansetron

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