The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction

Abstract

Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI). Materials and Methods: A total of 140 patients with NSTEMI undergoing coronary angiography were consecutively included in the study. The Synergy Between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score was determined based on initial coronary angiography by at least two separate cardiologists. Results: A positive correlation was found between high SSII and PTH (r = 0.458; P < 0.001). PTH could anticipate the extremity of CAD with 64.4% sensitivity and 65.3% specificity at 250 ng/mL cut-off value (area under the curve: 0.718, 95% confidence interval, 54.8 - 74.7; P < 0.001). Through regression analysis, PTH, hypertension, diabetes mellitus, family history, lymphocyte count, and pro-brain natriuretic peptide levels were found to be independent predictors of SSII. Conclusion: In patients with NSTEMI, serum PTH levels were significantly associated with higher SSII, an indicator of CAD severity and cardiovascular prognosis. This study obtained positive results that will contribute to our clinical interpretation. More comprehensive studies with PTH will make a more useful contribution to our clinical judgments.

Keywords

• pleiotrophin
• nstemi
• syntax score
• acute coronary syndrome
• coronary artery disease