Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker

Abdalla Sheikh; Abdalla Sheikh; Ninan Abraham; Ninan Abraham; Ninan Abraham

doi:10.3389/fimmu.2019.02897

Frontiers in Immunology (Dec 2019)

Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker

Abdalla Sheikh,
Abdalla Sheikh,
Ninan Abraham,
Ninan Abraham,
Ninan Abraham

Affiliations

Abdalla Sheikh: Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
Abdalla Sheikh: Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada
Ninan Abraham: Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
Ninan Abraham: Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada
Ninan Abraham: Department of Zoology, University of British Columbia, Vancouver, BC, Canada

DOI: https://doi.org/10.3389/fimmu.2019.02897
Journal volume & issue: Vol. 10

Abstract

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Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis. They share similar characteristics with various subsets of helper T cells but lack specific antigen receptors. Interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP) are cytokines that engage the IL-7Rα and have major roles in dictating the fate of ILCs. Recent advances in the field have revealed transcriptional programs associated with ILC development and function. In this article, we will review recent studies of the role of IL-7 and TSLP in ILC development and function during infection and inflammation.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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