Synergistic delivery of hADSC-Exos and antioxidants has inhibitory effects on UVB-induced skin photoaging
Yu Fu,
Jun-ling Xie,
Wan-ting Zhang,
Xing-liao Zhang,
Xin-Min Zhang,
Meng-meng Xu,
Yao-ting Han,
Rong-qi Liu,
Guang-ming Xie,
Jing Zhang,
Jun Zhang
Affiliations
Yu Fu
Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China
Jun-ling Xie
Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China
Wan-ting Zhang
Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China
Xing-liao Zhang
Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China
Xin-Min Zhang
Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China
Meng-meng Xu
Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China
Yao-ting Han
Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China
Rong-qi Liu
Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China
Guang-ming Xie
Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China
Jing Zhang
Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China; Tongji Lifeng Institute of Regenerative Medicine, Tongji University, Shanghai, 200092, China; Corresponding author. Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200010, China.
Jun Zhang
Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China; Tongji Lifeng Institute of Regenerative Medicine, Tongji University, Shanghai, 200092, China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200092, China; Corresponding author. Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China.
Ultraviolet B (UVB) light exposure accelerates skin photoaging. Human adipose-derived stem cell exosomes (hADSC-Exos) and some antioxidants may have anti-photoaging effects. However, it is unknown whether the combination of hADSC-Exos and antioxidants plays a synergistic role in anti-photoaging. In cellular and 3D skin models, we showed that vitamin E (VE) and hADSC-Exos were optimal anti-photoaging combinations. In vivo, VE and hADSC-Exos increased skin tightening and elasticity in UVB-induced photoaging mice Combined treatment with VE and hADSC-Exos inhibited SIRT1/NF-κB pathway. These findings contribute to the understanding of hADSC-Exos in conjunction with other antioxidants, thereby providing valuable insights for the future pharmaceutical and cosmetic industries.
