The <i>TMPRSS6</i> variant (SNP rs855791) affects iron metabolism and oral iron absorption – a stable iron isotope study in Taiwanese women
Simone Buerkli,
Sung-Nan Pei,
Shu-Chen Hsiao,
Chien-Te Lee,
Christophe Zeder,
Michael B. Zimmermann,
Diego Moretti
Affiliations
Simone Buerkli
Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland
Sung-Nan Pei
Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Hematology Oncology, E-Da Cancer Hospital, Taiwan; College of Medicine, I-Shou University, Kaohsiung, Taiwan
Shu-Chen Hsiao
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Taiwan
Chien-Te Lee
Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Christophe Zeder
Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland
Michael B. Zimmermann
Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland
Diego Moretti
Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland; Current address: Swiss Distance University of Applied Sciences, Department of Health, Regensdorf/Zurich, Switzerland
Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. We administered standardized ricebased test meals containing 4 mg of labeled 57Fe or 58Fe as FeSO4 on alternate days in non-anemic Taiwanese women (n=79, 44 TT variant, 35 CC variant). Fractional iron absorption was measured by erythrocyte incorporation of the tracers 14 days after administration. Compared to the CC variant, iron and transferrin saturation were lower (P=0.001; PT) polymorphism show altered iron homeostasis which affects oral iron absorption and may increase their risk for iron deficiency. The trial was registered as clinicaltrials gov. Identifier: NCT03317873, and funded by the Kaohsiung Chang-Gung Memorial Hospital, Kaohsiung, Taiwan, (grant CMRPG8F0721) and ETH Zurich, Switzerland.
