Effects of Message Framing and Time Discounting on Health Communication for Optimum Cardiovascular Disease and Stroke Prevention (EMT-OCSP): a protocol for a pragmatic, multicentre, observer-blinded, 12-month randomised controlled study
Yang Zhang,
Muke Zhou,
Li He,
Yanan Zhang,
Xiaodong Yang,
Cairong Zhu,
Yanbo Li,
Dong Zhou,
Ning Chen,
Quan He,
Jian Guo,
Mengmeng Ma,
Shuju Dong,
Jinghuan Fang,
Jiajia Bao,
Ye Hong,
You Lu,
Mingfang Qin,
Ling Yin,
Xianbin Ding,
Liyan Chen,
Zhuoqun Wang,
Shengquan Mi,
Shengyun Chen
Affiliations
Yang Zhang
6 Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, China
Muke Zhou
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Li He
7 The First Affiliated Hospital of Hebei University of Chinese Medicine, Hebei, China
Yanan Zhang
Center for Single-Cell Omics and Health, School of Public Health, Xi`an Jiaotong University Health Science Center, Xi`an, Shaanxi, China
Xiaodong Yang
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
Cairong Zhu
Department of Epidemic Disease & Health Statistics, School of Public Health, Sichuan University, Chengdu, China
Yanbo Li
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Dong Zhou
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Ning Chen
Department of Epidemiology and Biostatistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Quan He
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Jian Guo
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Mengmeng Ma
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Shuju Dong
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Jinghuan Fang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Jiajia Bao
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
Ye Hong
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
You Lu
Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China
Mingfang Qin
Department of Prevention & Control of Non-Communicable Chronic Diseases, Yunnan Center for Disease Control and Prevention, Kunming, China
Ling Yin
Chinese Academy of Sciences & Chinese Academy of Engineering, Zunyi Academician Center, Zunyi, China
Xianbin Ding
Institute of Chronic Non-Communicable Disease Control and Prevention, Chongqing Center for Disease Control and Prevention, Chongqing, China
Liyan Chen
Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Zhuoqun Wang
Department of Prevention & Control of Non-Communicable Chronic Diseases, Chinese Center for Disease Control and Prevention, Beijing, China
Shengquan Mi
Department of Food Science, College of Biochemical Engineering, Beijing Union University, Beijing, China
Shengyun Chen
Center of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Introduction Primary prevention of cardiovascular disease (CVD) and stroke often fails due to poor adherence among patients to evidence-based prevention recommendations. The proper formatting of messages portraying CVD and stroke risks and interventional benefits may promote individuals’ perception and motivation, adherence to healthy plans and eventual success in achieving risk control. The main objective of this study is to determine whether risk and intervention communication strategies (gain-framed vs loss-framed and long-term vs short-term contexts) and potential interaction thereof have different effects on the optimisation of adherence to clinical preventive management for the endpoint of CVD risk reduction among subjects with at least one CVD risk factor.Methods and analysis This trial is designed as a 2×2 factorial, observer-blinded multicentre randomised controlled study with four parallel groups. Trial participants are aged 45–80 years and have at least one CVD risk factor. Based on sample size calculations for primary outcome, we plan to enrol 15 000 participants. Data collection will occur at baseline, 6 months and 1 year after randomisation. The primary outcomes are changes in the estimated 10-year CVD risk, estimated lifetime CVD risk and estimated CVD-free life expectancy from baseline to the 1-year follow-up.Ethics and dissemination This study received approval from the Ethical Committee of West China Hospital, Sichuan University and will be disseminated via peer-reviewed publications and conference presentations.Trial registration number NCT04450888.
