A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells

Abstract

Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haematopoiesis in human cord blood and that they can give rise to erythroid megakaryocytic progenitors.