Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
Martyna Patalong-Wójcik,
Anna Golara,
Katarzyna Zając,
Alicja Sokołowska,
Mateusz Kozłowski,
Aleksandra Tołoczko-Grabarek,
Mariola Krzyścin,
Agnieszka Brodowska,
Agnieszka Janiec,
Aleksandra Myszka,
Aneta Cymbaluk-Płoska,
Elżbieta Sowińska-Przepiera
Affiliations
Martyna Patalong-Wójcik
Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University in Szczecin, UniiLubelskiej 1, 71-252 Szczecin, Poland
Anna Golara
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
Katarzyna Zając
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
Alicja Sokołowska
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
Mateusz Kozłowski
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
Aleksandra Tołoczko-Grabarek
Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland
Mariola Krzyścin
Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University in Szczecin, UniiLubelskiej 1, 71-252 Szczecin, Poland
Agnieszka Brodowska
Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, UniiLubelskiej 1, 71-252 Szczecin, Poland
Agnieszka Janiec
Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University in Szczecin, UniiLubelskiej 1, 71-252 Szczecin, Poland
Aleksandra Myszka
Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University in Szczecin, UniiLubelskiej 1, 71-252 Szczecin, Poland
Aneta Cymbaluk-Płoska
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
Elżbieta Sowińska-Przepiera
Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University in Szczecin, UniiLubelskiej 1, 71-252 Szczecin, Poland
Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can be used as an indicator in the assessment of bone mineralisation. The study included 111 patients. All patients had their bone mineral density determined in the L1–L4 section of the lumbar spine and in the whole skeleton. The parameters of fat mass (FM), lean body mass (LBM) and visceral fat mass (VF) were also determined. Metabolic activity of osteocytes was assessed by measuring the serum sclerostin concentration. There was a statistically significant association of both hands’ muscle strength with all parameters expressing bone mineralisation. A statistically significant relationship was also obtained between BMD L1–L4 and the body mass components (FM, LBM). Sclerostin levels in the study did not differ between groups with normal and reduced bone mineral density. Muscle strength assessment may be a potential exponent of reduced bone mineral density, also used clinically in young adult women. The utility of sclerostin in the clinical assessment of bone mineralisation has not been demonstrated.
