Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

Paulina Andrade; Ciara Gimblet-Ochieng; Faraz Modirian; Matthew Collins; Maritza Cárdenas; Leah C. Katzelnick; Magelda Montoya; Daniela Michlmayr; Guillermina Kuan; Angel Balmaseda; Josefina Coloma; Aravinda M. de Silva; Eva Harris

doi:10.1038/s41467-019-08845-3

Nature Communications (Feb 2019)

Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

Paulina Andrade,
Ciara Gimblet-Ochieng,
Faraz Modirian,
Matthew Collins,
Maritza Cárdenas,
Leah C. Katzelnick,
Magelda Montoya,
Daniela Michlmayr,
Guillermina Kuan,
Angel Balmaseda,
Josefina Coloma,
Aravinda M. de Silva,
Eva Harris

Affiliations

Paulina Andrade: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
Ciara Gimblet-Ochieng: Department of Microbiology and Immunology, University of North Carolina
Faraz Modirian: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
Matthew Collins: Department of Microbiology and Immunology, University of North Carolina
Maritza Cárdenas: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
Leah C. Katzelnick: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
Magelda Montoya: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
Daniela Michlmayr: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
Guillermina Kuan: Centro de Salud Sócrates Flores Vivas, Ministry of Health
Angel Balmaseda: Sustainable Sciences Institute
Josefina Coloma: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
Aravinda M. de Silva: Department of Microbiology and Immunology, University of North Carolina
Eva Harris: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley

DOI: https://doi.org/10.1038/s41467-019-08845-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Here, Andrade et al. assess the memory B cell (MBC) and antibody response to Zika virus (ZIKV) in individuals with and without prior dengue virus (DENV) infection and find that ZIKV infection elicits a robust and specific MBC response that is only modestly affected by the number of prior DENV infections.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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