Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states

Ziguang Lin; Suoqin Jin; Jefferson Chen; Zhuorui Li; Zhongqi Lin; Li Tang; Qing Nie; Bogi Andersen

doi:10.1038/s41467-020-19234-6

Nature Communications (Oct 2020)

Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states

Ziguang Lin,
Suoqin Jin,
Jefferson Chen,
Zhuorui Li,
Zhongqi Lin,
Li Tang,
Qing Nie,
Bogi Andersen

Affiliations

Ziguang Lin: Department of Biological Chemistry, School of Medicine, University of California
Suoqin Jin: Department of Mathematics, University of California
Jefferson Chen: Department of Biological Chemistry, School of Medicine, University of California
Zhuorui Li: Department of Biological Chemistry, School of Medicine, University of California
Zhongqi Lin: Department of Biological Chemistry, School of Medicine, University of California
Li Tang: Department of Biological Chemistry, School of Medicine, University of California
Qing Nie: Department of Mathematics, University of California
Bogi Andersen: Department of Biological Chemistry, School of Medicine, University of California

DOI: https://doi.org/10.1038/s41467-020-19234-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The interfollicular epidermis (IFE) is part of the epidermis but how it forms is unclear. Here, the authors perform scRNA sequencing at various developmental stages on the mouse epidermis and on deletion of Grhl3, showing IFE differentiation is gradual and that Grhl3 is needed for commitment to differentiation by regulating Wnt signalling pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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