Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

Kei-ichiro Arimoto; Sayuri Miyauchi; Ty D. Troutman; Yue Zhang; Mengdan Liu; Samuel A. Stoner; Amanda G. Davis; Jun-Bao Fan; Yi-Jou Huang; Ming Yan; Christopher K. Glass; Dong-Er Zhang

doi:10.1038/s41467-022-35348-5

Nature Communications (Jan 2023)

Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

Kei-ichiro Arimoto,
Sayuri Miyauchi,
Ty D. Troutman,
Yue Zhang,
Mengdan Liu,
Samuel A. Stoner,
Amanda G. Davis,
Jun-Bao Fan,
Yi-Jou Huang,
Ming Yan,
Christopher K. Glass,
Dong-Er Zhang

Affiliations

Kei-ichiro Arimoto: Moores UCSD Cancer Center, University of California San Diego
Sayuri Miyauchi: Moores UCSD Cancer Center, University of California San Diego
Ty D. Troutman: Department of Medicine, University of California San Diego
Yue Zhang: Division of Biological Sciences, University of California San Diego
Mengdan Liu: Division of Biological Sciences, University of California San Diego
Samuel A. Stoner: Moores UCSD Cancer Center, University of California San Diego
Amanda G. Davis: Moores UCSD Cancer Center, University of California San Diego
Jun-Bao Fan: Moores UCSD Cancer Center, University of California San Diego
Yi-Jou Huang: Division of Biological Sciences, University of California San Diego
Ming Yan: Moores UCSD Cancer Center, University of California San Diego
Christopher K. Glass: Department of Medicine, University of California San Diego
Dong-Er Zhang: Moores UCSD Cancer Center, University of California San Diego

DOI: https://doi.org/10.1038/s41467-022-35348-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 22

Abstract

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The induction of immunogenic cell death (ICD) can potentiate antitumour immunity. Here the authors show that USP18, a negative regulator of IFN signaling protects cancer cells from ICD by suppressing the expression of canonical and non-canonical IFN-stimulated genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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