Beyond conventional biomarkers: Emerging importance of extracellular vesicles in osteoarthritis, metabolic disorders and cardiovascular disease

Madison Coward-Smith; Ye Zhang; Chantal Donovan; Richard Y. Kim; Baoming Wang; Razia Zakarya; Hui Chen; Jiao Jiao Li; Brian G. Oliver

Extracellular Vesicle (Jun 2025)

Beyond conventional biomarkers: Emerging importance of extracellular vesicles in osteoarthritis, metabolic disorders and cardiovascular disease

Madison Coward-Smith,
Ye Zhang,
Chantal Donovan,
Richard Y. Kim,
Baoming Wang,
Razia Zakarya,
Hui Chen,
Jiao Jiao Li,
Brian G. Oliver

Affiliations

Madison Coward-Smith: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia
Ye Zhang: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia
Chantal Donovan: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia
Richard Y. Kim: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia
Baoming Wang: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia
Razia Zakarya: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia
Hui Chen: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia
Jiao Jiao Li: Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia; School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Sydney, NSW, Australia; Corresponding author. University of Technology Sydney, 15 Broadway, Ultimo, 2007, Australia.
Brian G. Oliver: School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Macquire University, Sydney, NSW, Australia; Corresponding author. University of Technology Sydney, 15 Broadway, Ultimo, 2007, Australia.

Journal volume & issue: Vol. 5
p. 100079

Abstract

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Extracellular vesicles (EVs), initially recognized for their roles in intercellular communication, are being increasingly explored for applications in the diagnosis and therapy of various diseases, particularly those driven by chronic inflammation. This review provides insight into the defining characteristics and functions of EVs, focusing on their role in contributing to and acting as potential therapeutics for chronic inflammatory diseases, including osteoarthritis, metabolic disorders such as obesity and metabolic dysfunction associated fatty liver disease, and cardiovascular diseases such as atherosclerosis and ischaemic stroke. Finally, the issues limiting EV translation from bench to bedside, and the outlook of EV research are discussed.

Published in Extracellular Vesicle

ISSN: 2773-0417 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Biology (General); Medicine: Medicine (General)
Website: https://www.sciencedirect.com/journal/extracellular-vesicle

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Abstract

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