Nature Communications (Jul 2021)

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

  • L. Vanderbeke,
  • P. Van Mol,
  • Y. Van Herck,
  • F. De Smet,
  • S. Humblet-Baron,
  • K. Martinod,
  • A. Antoranz,
  • I. Arijs,
  • B. Boeckx,
  • F. M. Bosisio,
  • M. Casaer,
  • D. Dauwe,
  • W. De Wever,
  • C. Dooms,
  • E. Dreesen,
  • A. Emmaneel,
  • J. Filtjens,
  • M. Gouwy,
  • J. Gunst,
  • G. Hermans,
  • S. Jansen,
  • K. Lagrou,
  • A. Liston,
  • N. Lorent,
  • P. Meersseman,
  • T. Mercier,
  • J. Neyts,
  • J. Odent,
  • D. Panovska,
  • P. A. Penttila,
  • E. Pollet,
  • P. Proost,
  • J. Qian,
  • K. Quintelier,
  • J. Raes,
  • S. Rex,
  • Y. Saeys,
  • J. Sprooten,
  • S. Tejpar,
  • D. Testelmans,
  • K. Thevissen,
  • T. Van Buyten,
  • J. Vandenhaute,
  • S. Van Gassen,
  • L. C. Velásquez Pereira,
  • R. Vos,
  • B. Weynand,
  • A. Wilmer,
  • J. Yserbyt,
  • A. D. Garg,
  • P. Matthys,
  • C. Wouters,
  • D. Lambrechts,
  • E. Wauters,
  • J. Wauters

DOI
https://doi.org/10.1038/s41467-021-24360-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

The host immune response plays a critical role in the immunopathology of SARS-CoV2. Here the authors combine a systems biology approach to implicate monocytes as key drivers of cytokine storm and disturbed neutrophil activation in COVID-19 disease severity.