PLoS ONE (Jan 2014)

Progesterone receptor status and Ki-67 index may predict early relapse in luminal B/HER2 negative breast cancer patients: a retrospective study.

  • Yu Zong,
  • Li Zhu,
  • Jiayi Wu,
  • Xiaosong Chen,
  • Ou Huang,
  • Xiaochun Fei,
  • Jianrong He,
  • Weiguo Chen,
  • Yafen Li,
  • Kunwei Shen

DOI
https://doi.org/10.1371/journal.pone.0095629
Journal volume & issue
Vol. 9, no. 8
p. e95629

Abstract

Read online

Few studies has documented early relapse in luminal B/HER2-negative breast cancer. We examined prognostic factors for early relapse among these patients to improve treatment decision-making.A total 398 patients with luminal B/HER2-negative breast cancer were included. Kaplan-Meier curves were applied to estimate disease-free survival and Cox regression to identify prognostic factors.Progesterone receptor (PR) negative expression was associated with higher tumor grade (p30%) had a reduced disease-free survival (DFS) when compared with low Ki-67 index group (≤30%) (98.0% vs 92.4%, respectively, Log-rank p = .013). In multivariate analysis, PR negativity was significantly associated with a reduced DFS (HR = 3.91, 95% CI 1.29-11.88, p = .016).In this study, PR negativity was a prognostic factor for early relapse in luminal B/HER2-negative breast cancer, while a high Ki-67 index suggested a higher risk of early relapse.