Molecules (Aug 2022)
Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides
- Denis V. Sudarikov,
- Yulia V. Gyrdymova,
- Alexander V. Borisov,
- Julia M. Lukiyanova,
- Roman V. Rumyantcev,
- Oksana G. Shevchenko,
- Diana R. Baidamshina,
- Nargiza D. Zakarova,
- Airat R. Kayumov,
- Ekaterina O. Sinegubova,
- Alexandrina S. Volobueva,
- Vladimir V. Zarubaev,
- Svetlana A. Rubtsova
Affiliations
- Denis V. Sudarikov
- Institute of Chemistry, FRC “Komi Scientific Centre”, Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia
- Yulia V. Gyrdymova
- Institute of Chemistry, FRC “Komi Scientific Centre”, Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia
- Alexander V. Borisov
- Department of Chemistry, Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin St., 603155 Nizhny Novgorod, Russia
- Julia M. Lukiyanova
- Department of Chemistry, Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin St., 603155 Nizhny Novgorod, Russia
- Roman V. Rumyantcev
- Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinina 49, 603950 Nizhny Novgorod, Russia
- Oksana G. Shevchenko
- Center of Collective Usage “Molecular Biology”, Institute of Biology, Komi Science Centre, Ural Branch of Russian Academy of Sciences, 28 Kommunisticheskaya Street, 167982 Syktyvkar, Russia
- Diana R. Baidamshina
- Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya St., 420008 Kazan, Russia
- Nargiza D. Zakarova
- Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya St., 420008 Kazan, Russia
- Airat R. Kayumov
- Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya St., 420008 Kazan, Russia
- Ekaterina O. Sinegubova
- Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., 197101 Saint Petersburg, Russia
- Alexandrina S. Volobueva
- Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., 197101 Saint Petersburg, Russia
- Vladimir V. Zarubaev
- Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., 197101 Saint Petersburg, Russia
- Svetlana A. Rubtsova
- Institute of Chemistry, FRC “Komi Scientific Centre”, Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia
- DOI
- https://doi.org/10.3390/molecules27165101
- Journal volume & issue
-
Vol. 27,
no. 16
p. 5101
Abstract
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.
Keywords
- unsymmetrical
- monoterpenylhetaryl disulfides
- antioxidant
- antibacterial
- antifungal activity
- cytotoxicity
