Nature Communications (Dec 2021)

Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy

  • Wenqing Li,
  • Xinfu Zhang,
  • Chengxiang Zhang,
  • Jingyue Yan,
  • Xucheng Hou,
  • Shi Du,
  • Chunxi Zeng,
  • Weiyu Zhao,
  • Binbin Deng,
  • David W. McComb,
  • Yuebao Zhang,
  • Diana D. Kang,
  • Junan Li,
  • William E. Carson,
  • Yizhou Dong

DOI
https://doi.org/10.1038/s41467-021-27434-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Antibodies targeting OX40 or CD137, two T cell costimulatory receptors, have been shown to improve antitumor immunity. Here the authors design a phospholipid-derived nanoparticle to deliver OX40 or CD137 mRNA to T cells in vivo, improving efficacy of anti-OX40 and anti-CD137 antibody therapy in preclinical tumor models.