Results in Chemistry (Jan 2024)
L-Aspartic acid pyridinium salts: In silico, synthesis and adjuvant vs antibiotic antibacterial evaluation
Abstract
In the present study, a new series of chiral L-aspartic acid pyridinium salts have been designed, guided by molecular docking as antiemetics via TrySR or DNA GryB inhibitors, as well as an adjuvant to chloramphenicol via CAT-III inhibitor to continue with antibacterial in vitro study. Newly designed molecules have been synthesized by chemistry route and their characterization was done by using NMR & HRMS techniques. Biological evaluation of synthesized compounds has been done on Gram-negative bacteria, to E. coli The in vitro evaluation results have shown that pyridinium salts 3a, 3e, 3i, 3j, 3k and 3o as an antibacterial, in addition to 3o and 3i, as an adjuvant against E. coli resistant to chloramphenicol.
