Nature Communications (Sep 2019)
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
- Wen Jing Sim,
- Prasanna Vasudevan Iyengar,
- Dilraj Lama,
- Sarah Kit Leng Lui,
- Hsien Chun Ng,
- Lior Haviv-Shapira,
- Eytan Domany,
- Dennis Kappei,
- Tuan Zea Tan,
- Azad Saei,
- Patrick William Jaynes,
- Chandra Shekhar Verma,
- Alan Prem Kumar,
- Mathieu Rouanne,
- Hong Koo Ha,
- Camelia Radulescu,
- Peter ten Dijke,
- Pieter Johan Adam Eichhorn,
- Jean Paul Thiery
Affiliations
- Wen Jing Sim
- Institute of Molecular and Cell Biology, A*STAR
- Prasanna Vasudevan Iyengar
- Cancer Science Institute of Singapore, National University of Singapore
- Dilraj Lama
- Bioinformatics Institute (A*STAR)
- Sarah Kit Leng Lui
- Cancer Science Institute of Singapore, National University of Singapore
- Hsien Chun Ng
- Institute of Molecular and Cell Biology, A*STAR
- Lior Haviv-Shapira
- Department of Physics of Complex Systems, The Weizmann Institute of Science
- Eytan Domany
- Department of Physics of Complex Systems, The Weizmann Institute of Science
- Dennis Kappei
- Cancer Science Institute of Singapore, National University of Singapore
- Tuan Zea Tan
- Cancer Science Institute of Singapore, National University of Singapore
- Azad Saei
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Patrick William Jaynes
- Cancer Science Institute of Singapore, National University of Singapore
- Chandra Shekhar Verma
- Bioinformatics Institute (A*STAR)
- Alan Prem Kumar
- Cancer Science Institute of Singapore, National University of Singapore
- Mathieu Rouanne
- Department of Urology, Hôpital Foch, Université Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay
- Hong Koo Ha
- Department of Urology, Pusan National University Hospital, Pusan National University School of Medicine
- Camelia Radulescu
- Department of Pathology, Hôpital Foch, Université Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay
- Peter ten Dijke
- Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center
- Pieter Johan Adam Eichhorn
- Cancer Science Institute of Singapore, National University of Singapore
- Jean Paul Thiery
- Institute of Molecular and Cell Biology, A*STAR
- DOI
- https://doi.org/10.1038/s41467-019-12241-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.
