Nature Communications (Apr 2023)
TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques
- Amit A. Upadhyay,
- Elise G. Viox,
- Timothy N. Hoang,
- Arun K. Boddapati,
- Maria Pino,
- Michelle Y.-H. Lee,
- Jacqueline Corry,
- Zachary Strongin,
- David A. Cowan,
- Elizabeth N. Beagle,
- Tristan R. Horton,
- Sydney Hamilton,
- Hadj Aoued,
- Justin L. Harper,
- Christopher T. Edwards,
- Kevin Nguyen,
- Kathryn L. Pellegrini,
- Gregory K. Tharp,
- Anne Piantadosi,
- Rebecca D. Levit,
- Rama R. Amara,
- Simon M. Barratt-Boyes,
- Susan P. Ribeiro,
- Rafick P. Sekaly,
- Thomas H. Vanderford,
- Raymond F. Schinazi,
- Mirko Paiardini,
- Steven E. Bosinger
Affiliations
- Amit A. Upadhyay
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Elise G. Viox
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Timothy N. Hoang
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Arun K. Boddapati
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Maria Pino
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Michelle Y.-H. Lee
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Jacqueline Corry
- Department of Infectious Diseases and Microbiology, University of Pittsburgh
- Zachary Strongin
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- David A. Cowan
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Elizabeth N. Beagle
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Tristan R. Horton
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Sydney Hamilton
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Hadj Aoued
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Justin L. Harper
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Christopher T. Edwards
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Kevin Nguyen
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Kathryn L. Pellegrini
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Gregory K. Tharp
- Emory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University
- Anne Piantadosi
- Department of Pathology and Laboratory Medicine, School of Medicine, Emory University
- Rebecca D. Levit
- Department of Medicine, School of Medicine, Emory University
- Rama R. Amara
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Simon M. Barratt-Boyes
- Department of Infectious Diseases and Microbiology, University of Pittsburgh
- Susan P. Ribeiro
- Department of Pathology and Laboratory Medicine, School of Medicine, Emory University
- Rafick P. Sekaly
- Department of Pathology and Laboratory Medicine, School of Medicine, Emory University
- Thomas H. Vanderford
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Raymond F. Schinazi
- Department of Pediatrics, School of Medicine, Emory University and Children’s Healthcare of Atlanta
- Mirko Paiardini
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- Steven E. Bosinger
- Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University
- DOI
- https://doi.org/10.1038/s41467-023-37425-9
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
‘The induction and coordination of immune cells in response to SARS-CoV-2 infection are critical in the immunopathology of COVID-19. Here the authors use a rhesus macaque model of SARS-CoV-2 infection and show key populations of macrophage drive the inflammatory cytokine production in the alveolar space’.
