Journal of Blood Medicine (Jun 2021)
Different Types of Minor Blood Group Incompatibility Causing Haemolytic Disease of Neonates in one of the National Children’s Medical Centre in China
Abstract
Mingchun Lin,1,2 Meixiu Liu,3 Shulian Zhang,1 Chao Chen,1 Jin Wang1 1Neonatal Department, Children’s Hospital of Fudan University, Shanghai, 201102, People’s Republic of China; 2Neonatal Fellowship Training at Children’s Hospital of Fudan University, Yueqing Maternal and Child Health Hospital, Wenzhou, Zhejiang Province, People’s Republic of China; 3Blood Bank, Children’s Hospital of Fudan University, Shanghai, 201102, People’s Republic of ChinaCorrespondence: Jin WangNeonatal Department, Children’s Hospital of Fudan University, No. 399, Wanyuan Road, Shanghai, 201102, People’s Republic of ChinaTel +86-21-64932960Email [email protected]: To review the neonatal cases with different types of minor blood group incompatible haemolytic diseases in China, and to improve the clinical understanding and management.Materials and Methods: Seven cases from January, 1st, 2013 to December 31st, 2019 were searched out and reviewed retrospectively. All clinical data and laboratory findings were collected.Results: There were totally seven cases enrolled including three cases of MNS, three of Diego, and one of Kidd combined with Rh, anti-RhE incompatibility. Among the seven cases, two had intrauterine transfusion, two underwent exchange transfusion, five received intravenous immune globulin, five cases developed anaemia, and three of them had transfusion. But among them, only four were found to have positive antibody screening and three were confirmed HDN with antibody types antenatally.Conclusion: The clinical presentation is diverse. Antibody screening followed by the technique of peak systolic velocity in the fetal middle cerebral artery (MCA-PSV) helps to filter out the severe cases.Keywords: neonatal haemolytic disease, HDN, alloimmunization, MNS blood group, Diego blood group, Kidd blood group
