Oil-in-water strategy coating Curcumin-nido-Carborane fluorescent complex with acrylic resins for cell imaging

Abstract

Using curcumin and carborane as raw materials, four different kinds of curcumin fluorescent complexes RL-100-Curcumin (RL-100-Cur), RS-100-Curcumin (RS-100-Cur), RL-100-Curcumin -Carborane (RL-100-Cur-B) and RS-100-Curcumin-Carborane (RS-100-Cur-B) were prepared by one-pot method, which solved the shortcomings of curcumin's poor solubility and improved the biocompatibility of curcumin-carboranes. The prepared fluorescent complexes were characterized by infrared spectroscopy, and the characteristic peaks at 1634 cm−1 (aromatic), 1732 cm−1 (carbonyl) and 2568 cm−1 (boron) were confirmed. The coating of curcumin-carborane into nano-spheres by acrylic resin carrier can be observed by transmission electron microscope. Acrylic resins RL-100 and RS-100 are zwitteric ionic polychloride polymer materials, which can be firmly combined with polar or ionic molecules in the form of hydrogen or ionic bonds to form regular nanoparticle. Through in vitro tumor cell imaging, it was observed that the four kinds of curcumin fluorescent complexes had good biocompatibility and accurately entered into tumor cells, indicating that the four compounds had certain selectivity. This design not only solves the problem of curcumin-carborane bioavailability but also has a certain visual fluorescence targeting effect. In particular, the properties of RS-100-Cur-B are particularly obvious.

Keywords

• Curcumin
• Carborone
• Oil-in-water
• Acrylic resin
• Cell imaging