Future Science OA (Dec 2024)

Hematological, inflammatory and serological responses among COVID-19 patients admitted to intensive care unit

  • Mirette A Morgan,
  • Sarra E Saleh,
  • Azza H Salamoni,
  • Mohammad Y Alshahrani,
  • Khaled M Aboshanab

DOI
https://doi.org/10.1080/20565623.2024.2389664
Journal volume & issue
Vol. 10, no. 1

Abstract

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Aim: To correlate hematological, inflammatory indicators and serological responses among COVID-19 patients to point out the significant biomarkers for disease management and prognosis.Materials & methods: Standard analytical and molecular methods were used to assess various inflammatory and serological Responses among COVID-19 patients (ICU- (n = 99) and non-ICU patients (n = 64) as compared with health control (n = 40).Results: Significant differences in the Hb, WBC, Lymphocyte count, CRP and serum ferritin (p < 0.05) were observed. Patients' IgM/IgG antibodies against SARS-CoV-2 were associated with increased CRP, LDH and serum ferritin levels.Conclusion: A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission.

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