Two New Diterpenoids from the Buds of <em>Wikstroemia chamaedaphne</em>

Abstract

Two new diterpenoids, wikstroelide Q (<strong>1</strong>) and prostratin Q (<strong>5</strong>), together with three known diterpenoids, pimelea factors P₂ (<strong>2</strong>), P₃ (<strong>3</strong>), and prostratin (<strong>4</strong>), and five known lignans, (+)-epipioresinol (<strong>6</strong>), (+)-isolariciresinol (<strong>7</strong>), (−)-lariciresinol (<strong>8</strong>), (+)-<em>epi</em>-sesaminone (<strong>9</strong>), and prestegane B (<strong>10</strong>), were isolated from the<em> </em>buds of <em>Wikstroemia chamaedaphne</em> Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds <strong>1</strong>–<strong>10</strong> were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines<em> in vitro</em>.

Keywords

• &lt;em&gt;Wikstroemia chamaedaphne&lt;/em&gt;
• diterpenoids
• lignans
• cytotoxicity