Multifactor Assessment of Metabolic Syndrome Risk in Uzbek Children and Adolescents with Obesity

Abstract

Metabolic syndrome (MetS) contributes to early atherosclerotic changes of blood vessels and type 2 diabetes mellitusnot only among adults, but among children and adolescents, causing onset and progression of severe diseases resulting in early disablement and death. Multifactor analysis of MetS risk in Uzbek children and adolescents with exogenous-constitutional obesity (ECO) was the purpose of the study. The study included 100 Uzbek children and adolescents with ECO aged from 6 to 16 (mean age 11.7±0.25 years)—54(54.0%) boys and 46(46.0%) girls. Prognostic matrix was made up by means of a modification of Bayesian probability by E. Shigan (1986). Mathematical analysis confirmed a high degree of risk for MetS onset and progression in obese patients with disorders of lipid profile and hemodynamics. MetS risk is 8.2 times higher with levels of HDL-C 3.0, HbA1c >6.7%, and obesity onset before 5 years of age.

Keywords

• obesity;
• metabolic syndrome;
• adolescents;
• children;