Cyclodextrin-Based Pickering Emulsion Significantly Increases 6-Gingerol Loading Through Two Different Mechanisms: Cyclodextrin Cavity and Pickering Core
Xingran Kou,
Dongdong Su,
Jingzhi Zhang,
Fei Pan,
Jiamin Zhu,
Qingran Meng,
Qinfei Ke
Affiliations
Xingran Kou
Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China
Dongdong Su
Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and Aroma Technology (Shanghai Research Institute of Fragrance & Flavour Industry), Shanghai Institute of Technology, Shanghai 201418, China
Jingzhi Zhang
Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and Aroma Technology (Shanghai Research Institute of Fragrance & Flavour Industry), Shanghai Institute of Technology, Shanghai 201418, China
Fei Pan
State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China
Jiamin Zhu
Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and Aroma Technology (Shanghai Research Institute of Fragrance & Flavour Industry), Shanghai Institute of Technology, Shanghai 201418, China
Qingran Meng
Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and Aroma Technology (Shanghai Research Institute of Fragrance & Flavour Industry), Shanghai Institute of Technology, Shanghai 201418, China
Qinfei Ke
Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China
We previously found that host–guest interactions can drive gingerols (Gs) and cyclodextrins (CDs) together to form inclusion complexes (G/CD), which can further construct amphiphilic microcrystals and resultant Pickering emulsions through self-assembly. In this follow-up study, we explored the detailed formation processes and mechanisms of the 6-G/β-CD inclusion complex and the resultant Pickering emulsion. The influence of the 6-G/β-CD molar ratio on the structure, morphology, and loading capacity of the inclusion complex and resultant Pickering emulsion were investigated. The results show that the cyclodextrin-based Pickering emulsion can load 6-G in two places; one place is the cyclodextrin cavity, whose loading capacity is up to 9.28%, while the other one is the Pickering core, with its highest loading capacity at 32.31% when the 6-G/β-CD molar ratio is 5:1. In the above case, the 6-G/β-CD inclusion complex was found to form a unit cell with a 1:2 molar ratio and then self-assemble into amphiphilic microcrystals through cage-type arrangement structures at the oil–water interface, mainly driven by van der Waals forces and hydrogen bonds. This study is helpful in the design and preparation of CD-based high-loading carriers for bioactive compound delivery.
