Communications Biology (Mar 2021)
Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
- Maud Voisin,
- Elina Shrestha,
- Claire Rollet,
- Cyrus A. Nikain,
- Tatjana Josefs,
- Mélanie Mahé,
- Tessa J. Barrett,
- Hye Rim Chang,
- Rachel Ruoff,
- Jeffrey A. Schneider,
- Michela L. Garabedian,
- Chris Zoumadakis,
- Chi Yun,
- Bara Badwan,
- Emily J. Brown,
- Adam C. Mar,
- Robert J. Schneider,
- Ira J. Goldberg,
- Inés Pineda-Torra,
- Edward A. Fisher,
- Michael J. Garabedian
Affiliations
- Maud Voisin
- Department of Microbiology, NYU School of Medicine
- Elina Shrestha
- Department of Microbiology, NYU School of Medicine
- Claire Rollet
- Department of Microbiology, NYU School of Medicine
- Cyrus A. Nikain
- Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, NYU School of Medicine
- Tatjana Josefs
- Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, NYU School of Medicine
- Mélanie Mahé
- Department of Microbiology, NYU School of Medicine
- Tessa J. Barrett
- Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, NYU School of Medicine
- Hye Rim Chang
- Division of Endocrinology, Department of Medicine, NYU School of Medicine
- Rachel Ruoff
- Department of Microbiology, NYU School of Medicine
- Jeffrey A. Schneider
- Department of Microbiology, NYU School of Medicine
- Michela L. Garabedian
- Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, NYU School of Medicine
- Chris Zoumadakis
- Ordaos, Inc
- Chi Yun
- Ordaos, Inc
- Bara Badwan
- Ordaos, Inc
- Emily J. Brown
- Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, NYU School of Medicine
- Adam C. Mar
- Department of Neuroscience and Physiology, NYU School of Medicine
- Robert J. Schneider
- Department of Microbiology, NYU School of Medicine
- Ira J. Goldberg
- Division of Endocrinology, Department of Medicine, NYU School of Medicine
- Inés Pineda-Torra
- Centre for Cardiometabolic and Vascular Science, University College of London
- Edward A. Fisher
- Division of Cardiology, Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, NYU School of Medicine
- Michael J. Garabedian
- Department of Microbiology, NYU School of Medicine
- DOI
- https://doi.org/10.1038/s42003-021-01925-5
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 18
Abstract
Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in macrophages and T cells to promote an anti-inflammatory phenotype, thus identifying a functional role of LXRα pS196 in immune cells.
