Frontiers in Microbiology (Jul 2019)

The Microbiome of Prostate Fluid Is Associated With Prostate Cancer

  • Xiaowei Ma,
  • Xiaowei Ma,
  • Chenfei Chi,
  • Liancheng Fan,
  • Baijun Dong,
  • Xiaoguang Shao,
  • Shaowei Xie,
  • Min Li,
  • Wei Xue

DOI
https://doi.org/10.3389/fmicb.2019.01664
Journal volume & issue
Vol. 10

Abstract

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ObjectivesTo explore the microbiome of the prostatic fluid in high prostate-specific antigen (PSA) patients.Patients and MethodsThe microbiome profiles of prostatic fluid samples from 32 prostate cancer (PCa) patients and 27 non-PCa people were assessed. Microbiome analysis was assessed by massive 16S ribosomal RNA gene sequencing.ResultsCompared with the NCA group, the microbial diversity was lower in the CA group. There were no specific microbial species in the CA group or NCA group. However, many species, such as those in the genera Alkaliphilus, Enterobacter, Lactococcus, Cronobacter, Carnobacterium, and Streptococcus, showed a significant difference between the CA group and NCA group.ConclusionThe prostate contains reduced bacteria, suggesting a possible pathophysiological correlation between the composition of the microbiome and PCa. Meanwhile, this study uncovered that the microbiome may be beneficial in maintaining the stability of the microenvironment of the prostate and provides interesting perspectives for the identification of novel biomarkers in high-PSA patients.

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