Multidrug Resistant <i>Pseudomonas aeruginosa</i> in Clinical Settings: A Review of Resistance Mechanisms and Treatment Strategies
Beth Schwartz,
Katherine Klamer,
Justin Zimmerman,
Pramodini B. Kale-Pradhan,
Ashish Bhargava
Affiliations
Beth Schwartz
Department of Internal Medicine, Henry Ford St. John Hospital, Detroit, MI 48236, USA
Katherine Klamer
Thomas Mackey Center for Infectious Disease, Henry Ford St. John Hospital, Detroit, MI 48201, USA
Justin Zimmerman
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Science, Wayne State University, Henry Ford St. John Hospital, Detroit, MI 48201, USA
Pramodini B. Kale-Pradhan
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Science, Wayne State University, Henry Ford St. John Hospital, Detroit, MI 48201, USA
Ashish Bhargava
Thomas Mackey Center for Infectious Disease, Henry Ford St. John Hospital, Detroit, MI 48201, USA
Pseudomonas aeruginosa is causing increasing concern among clinicians due to its high mortality and resistance rates. This bacterium is responsible for various infections, especially in hospital settings, affecting some of the most vulnerable patients. Pseudomonas aeruginosa has developed resistance through multiple mechanisms, making treatment challenging. Diagnostic techniques are evolving, with rapid testing systems providing results within 4–6 h. New antimicrobial agents are continuously being developed, offering potential solutions to these complex clinical decisions. This article provides a review of the epidemiology, at-risk populations, resistance mechanisms, and diagnostic and treatment options for Pseudomonas aeruginosa.
