Molecules
(Apr 2017)
Base-Promoted Synthesis of β-Substituted-Tryptophans via a Simple and Convenient Three-Component Condensation of Nickel(II) Glycinate
Rui Zhou,
Zhaoping Pan,
Yuehua Zhang,
Fengbo Wu,
Qinglin Jiang,
Li Guo
Affiliations
Rui Zhou
West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China
Zhaoping Pan
West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China
Yuehua Zhang
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
Fengbo Wu
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
Qinglin Jiang
Department of Medicinal Chemistry, School of Pharmacy, Chengdu Medical College, Chengdu 610500, Sichuan, China
Li Guo
West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China
DOI
https://doi.org/10.3390/molecules22050695
Journal volume & issue
Vol. 22,
no. 5
Abstract
Read online
A three-component reaction of nickel(II) glycinate was conducted for the convenient synthesis of β-substituted-tryptophans. The reaction worked smoothly under mild conditions and the procedure was simple and easy to handle.
Keywords
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