Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity.

Abstract

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Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload -such as heart failure- and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option.

Keywords

• Hypertension
• kidney disease
• renal denervation
• sympathetic activity