Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11

Ivan Zadra; Senda Jimenez-Delgado; Miquel Anglada-Girotto; Carolina Segura-Morales; Zachary J. Compton; Carsten Janke; Luis Serrano; Verena Ruprecht; Isabelle Vernos

doi:10.1038/s41467-022-34909-y

Nature Communications (Nov 2022)

Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11

Ivan Zadra,
Senda Jimenez-Delgado,
Miquel Anglada-Girotto,
Carolina Segura-Morales,
Zachary J. Compton,
Carsten Janke,
Luis Serrano,
Verena Ruprecht,
Isabelle Vernos

Affiliations

Ivan Zadra: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Senda Jimenez-Delgado: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Miquel Anglada-Girotto: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Carolina Segura-Morales: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Zachary J. Compton: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Carsten Janke: Institut Curie, Université PSL, CNRS UMR3348
Luis Serrano: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Verena Ruprecht: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Isabelle Vernos: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-34909-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The authors show that polyglutamylation of spindle microtubules is essential for error-free chromosome segregation and is mediated through Tubulin Tyrosine Ligase Like 11 (TTLL11), which is found to be frequently downregulated in cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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