Nature Communications (Aug 2017)
Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
Abstract
The use of gene silencing techniques in the treatment of post-transplantation host rejection is not long lasting and can have systemic effects. Here, the authors utilize a nanocarrier for siRNA for treatment of arteries ex vivo prior to implantation subsequently attenuating immune reaction in vivo.