Nature Communications (Aug 2017)

Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells

  • Jiajia Cui,
  • Lingfeng Qin,
  • Junwei Zhang,
  • Parwiz Abrahimi,
  • Hong Li,
  • Guangxin Li,
  • Gregory T. Tietjen,
  • George Tellides,
  • Jordan S. Pober,
  • W. Mark Saltzman

DOI
https://doi.org/10.1038/s41467-017-00297-x
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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The use of gene silencing techniques in the treatment of post-transplantation host rejection is not long lasting and can have systemic effects. Here, the authors utilize a nanocarrier for siRNA for treatment of arteries ex vivo prior to implantation subsequently attenuating immune reaction in vivo.