Nature Communications (Sep 2016)

CDK1 phosphorylates WRN at collapsed replication forks

  • Valentina Palermo,
  • Sara Rinalducci,
  • Massimo Sanchez,
  • Francesca Grillini,
  • Joshua A. Sommers,
  • Robert M. Brosh,
  • Lello Zolla,
  • Annapaola Franchitto,
  • Pietro Pichierri

DOI
https://doi.org/10.1038/ncomms12880
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks.