Psychology Research and Behavior Management (Dec 2023)

Effects of Health-Promoting Lifestyle on Late-Onset Depression in Older Adults: Mediating Effect of Meaning in Life and Interleukin-6 (IL-6)

  • Zhu M,
  • Zhao J,
  • Zhu X,
  • Cheng Q,
  • Zhang S,
  • Kong L

Journal volume & issue
Vol. Volume 16
pp. 5159 – 5168

Abstract

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Miao Zhu,1 Juan Zhao,1 Xiaoli Zhu,2 Qi Cheng,2 Shuyou Zhang,2 Lingming Kong2 1Psychiatry Department, The Oriental People’s Hospital of Xuzhou, Xuzhou, 221004, People’s Republic of China; 2Psychological Intervention Center, No.904 Hospital, Changzhou, 213003, People’s Republic of ChinaCorrespondence: Lingming Kong, Psychological Intervention Center, No.904th Hospital, Peace Road 55, Changzhou, Jiangsu, 213003, People’s Republic of China, Tel +86 519 83064556, Fax +8651983064560, Email [email protected]: Late-onset depression (LOD) with poor treatment response has high incidence and mortality in the China’s aged people, this study aims to explore the correlation between health-promoting lifestyle, meaning in life, interleukin-6 (IL-6) and LOD for providing scientific basis of LOD prevention and rehabilitation.Patients and Methods: A total of 496 LOD patients (study group) and healthy older adults (control group) were enrolled and investigated by using the Health-promoting lifestyle Profile-II, revised (HPLP-IIR), Meaning in Life Questionnaire-Chinese Version (MLQ-C), and Hamilton Depression Scale (HAMD). The interleukin-6 (IL-6) in the circulating blood was detected by utilizing ELISA kit.Results: The results showed that the scores of all factors in HPLP-IIR and MLQ were significantly lower and IL-6 level was higher in the study group than the control group. Scores of most factors in HPLP-IIR and MLQ negatively and IL-6 positively correlated with scores of subscales and total HAMD score. Meaning in life and IL-6 partially mediated the relationship between health-promoting lifestyles and depression severity in the study group, with the mediating effect explains 15.76% and 22.64% of the total effect, respectively.Conclusion: Health-promoting lifestyles, meaning in life, and IL-6 are predictors of LOD, and an unhealthy lifestyle could induce LOD through the mediating effect of meaning in life and IL-6 in older adults.Keywords: late-onset depression, meaning in life, health-promoting lifestyle, older adult

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