DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

• Jyoti Nangalia,
• Francesca L. Nice,
• David C. Wedge,
• Anna L Godfrey,
• Jacob Grinfeld,
• Clare Thakker,
• Charlie E. Massie,
• Joanna Baxter,
• David Sewell,
• Yvonne Silber,
• Peter J. Campbell,
• Anthony R. Green

Affiliations

Jyoti Nangalia

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK;Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK;Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

Francesca L. Nice

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK

David C. Wedge

Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

Anna L Godfrey

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK;Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK

Jacob Grinfeld

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK;Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK;Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

Clare Thakker

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK

Charlie E. Massie

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK

Joanna Baxter

Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK;Cambridge Blood and Stem Cell Bank, University of Cambridge, UK

David Sewell

Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK;Cambridge Blood and Stem Cell Bank, University of Cambridge, UK

Yvonne Silber

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK

Peter J. Campbell

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK;Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK;Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

Anthony R. Green

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK;Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK