Optimization of Chitosan Microspheres Spray Drying via 32 Full Factorial Design

Katsarov Plamen D.; Pilicheva Bissera A.; Manev Hristo M.; Lukova Paolina K.; Kassarova Margarita I.

doi:10.1515/folmed-2017-0037

Folia Medica (Sep 2017)

Optimization of Chitosan Microspheres Spray Drying via 32 Full Factorial Design

Katsarov Plamen D.,
Pilicheva Bissera A.,
Manev Hristo M.,
Lukova Paolina K.,
Kassarova Margarita I.

Affiliations

Katsarov Plamen D.: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria
Pilicheva Bissera A.: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria
Manev Hristo M.: Department of Medical Informatics, Biostatistics and Electronic Education, Faculty of Public Health, Medical University of Plovdiv, Plovdiv, Bulgaria
Lukova Paolina K.: Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria
Kassarova Margarita I.: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria

DOI: https://doi.org/10.1515/folmed-2017-0037
Journal volume & issue: Vol. 59, no. 3
pp. 310 – 317

Abstract

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Background: Generally, the preparation of spray-dried microspheres is strongly affected by the process parameters. Particle size and production yield are mainly influenced by the spraying solution concentration and the pump rate of the spray dryer.

Published in Folia Medica

ISSN: 0204-8043 (Print); 1314-2143 (Online)
Publisher: Pensoft Publishers
Country of publisher: Bulgaria
LCC subjects: Medicine
Website: https://foliamedica.bg

About the journal

Abstract

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