Distinctive molecular features of regenerative stem cells in the damaged male germline

Hue M. La; Jinyue Liao; Julien M. D. Legrand; Fernando J. Rossello; Ai-Leen Chan; Vijesh Vaghjiani; Jason E. Cain; Antonella Papa; Tin Lap Lee; Robin M. Hobbs

doi:10.1038/s41467-022-30130-z

Nature Communications (May 2022)

Distinctive molecular features of regenerative stem cells in the damaged male germline

Hue M. La,
Jinyue Liao,
Julien M. D. Legrand,
Fernando J. Rossello,
Ai-Leen Chan,
Vijesh Vaghjiani,
Jason E. Cain,
Antonella Papa,
Tin Lap Lee,
Robin M. Hobbs

Affiliations

Hue M. La: Centre for Reproductive Health, Hudson Institute of Medical Research
Jinyue Liao: Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Julien M. D. Legrand: Centre for Reproductive Health, Hudson Institute of Medical Research
Fernando J. Rossello: Australian Regenerative Medicine Institute, Monash University
Ai-Leen Chan: Centre for Reproductive Health, Hudson Institute of Medical Research
Vijesh Vaghjiani: Department of Molecular and Translational Sciences, Monash University
Jason E. Cain: Department of Molecular and Translational Sciences, Monash University
Antonella Papa: Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
Tin Lap Lee: Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Robin M. Hobbs: Centre for Reproductive Health, Hudson Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-022-30130-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Male germline regeneration after damage is dependent on spermatogonial stem cells (SSCs) but pathways mediating the regenerative response are unclear. Here the authors define roles for growth factor signalling and mTORC1 in SSC-driven regeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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