Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection

Abstract

In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit of Detection below 5 × 10−7 RIU. On sensors functionalized with Fab′, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated.

Keywords

• Mach–Zehnder interferometer
• biosensor
• Aflatoxin M1
• limit of detection
• Fab′