Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population

Xiaoyan Gao; Fei Ma; Hu Hao; Yiheng Dai; Weidong Liu; Xin Xiao; Pingmin Gao; Sitao Li

doi:10.1016/j.pedneo.2018.07.002

Pediatrics and Neonatology (Apr 2019)

Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population

Xiaoyan Gao,
Fei Ma,
Hu Hao,
Yiheng Dai,
Weidong Liu,
Xin Xiao,
Pingmin Gao,
Sitao Li

Affiliations

Xiaoyan Gao: Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China
Fei Ma: Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Hu Hao: Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Yiheng Dai: Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China
Weidong Liu: Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China
Xin Xiao: Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Corresponding author. Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26 Yuancun Erheng Road, Tianhe District, Guangzhou, 510655, China, Fax: +86 0 20 3877 7850.
Pingmin Gao: Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China; Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China; Corresponding author. Foshan Institute of Fetal Medicine, Southern Medical University, Affiliated Maternal and Child Health Hospital of Foshan, No. 11 Renmin, West Road, Chancheng District, Foshan, 528000, China
Sitao Li: Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Corresponding author. Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26 Yuancun Erheng Road, Tianhe District, Guangzhou, 510655, China.

DOI: https://doi.org/10.1016/j.pedneo.2018.07.002
Journal volume & issue: Vol. 60, no. 2
pp. 129 – 134

Abstract

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Background: To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population. Material and methods: Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay. Results: The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC. Conclusion: Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future. Key Words: necrotizing enterocolitis, preterm infants, single-nucleotide polymorphism, VEGFA

Published in Pediatrics and Neonatology

ISSN: 1875-9572 (Print); 2212-1692 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Pediatrics
Website: https://www.sciencedirect.com/journal/pediatrics-and-neonatology

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