Mpox Resurgence: A Multifaceted Analysis for Global Preparedness
Fatouma Mohamed Abdoul-Latif,
Ayoub Ainane,
Houda Mohamed,
Ali Merito Ali,
Ibrahim Houmed Aboubaker,
Pannaga Pavan Jutur,
Tarik Ainane
Affiliations
Fatouma Mohamed Abdoul-Latif
Medicinal Research Institute, Center for Research and Study of Djibouti, Djibouti P.O. Box 486, Djibouti
Ayoub Ainane
Superior School of Technology, University of Sultan Moulay Slimane, P.O. Box 170, Khenifra 54000, Morocco
Houda Mohamed
Medicinal Research Institute, Center for Research and Study of Djibouti, Djibouti P.O. Box 486, Djibouti
Ali Merito Ali
Medicinal Research Institute, Center for Research and Study of Djibouti, Djibouti P.O. Box 486, Djibouti
Ibrahim Houmed Aboubaker
Medicinal Research Institute, Center for Research and Study of Djibouti, Djibouti P.O. Box 486, Djibouti
Pannaga Pavan Jutur
Omics of Algae Group, Industrial Biotechnology, International Centre for Genetic Engineering and Bio-Technology, Aruna Asaf Ali Marg, New Delhi 110067, India
Tarik Ainane
Superior School of Technology, University of Sultan Moulay Slimane, P.O. Box 170, Khenifra 54000, Morocco
This study provides an in-depth analysis of mpox, encompassing its history, characteristics, epidemiology, diagnostics, treatment options, and the ongoing evolution of the virus and its transmission dynamics. Mpox, though once successfully eradicated, has re-emerged with new modes of transmission and a broader host range. Genomic analyses have revealed the virus’s adaptability, posing challenges for diagnostics and vaccine efficacy. The epidemiology has shifted from sporadic zoonotic transmission in rural Africa to a significant presence in urban areas, particularly impacting high-risk populations. Advancements in diagnostics and therapeutics offer hope, but challenges persist. This work underscores the critical need for enhanced surveillance, vaccination strategies, and continued research to bolster global health systems and preparedness for future outbreaks.
