Nature Communications (Feb 2018)
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
- Fumitaka Mizoguchi,
- Kamil Slowikowski,
- Kevin Wei,
- Jennifer L. Marshall,
- Deepak A. Rao,
- Sook Kyung Chang,
- Hung N. Nguyen,
- Erika H. Noss,
- Jason D. Turner,
- Brandon E. Earp,
- Philip E. Blazar,
- John Wright,
- Barry P. Simmons,
- Laura T. Donlin,
- George D. Kalliolias,
- Susan M. Goodman,
- Vivian P. Bykerk,
- Lionel B. Ivashkiv,
- James A. Lederer,
- Nir Hacohen,
- Peter A. Nigrovic,
- Andrew Filer,
- Christopher D. Buckley,
- Soumya Raychaudhuri,
- Michael B. Brenner
Affiliations
- Fumitaka Mizoguchi
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Kamil Slowikowski
- Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
- Kevin Wei
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Jennifer L. Marshall
- Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital
- Deepak A. Rao
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Sook Kyung Chang
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Hung N. Nguyen
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Erika H. Noss
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Jason D. Turner
- Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital
- Brandon E. Earp
- Department of Orthopedic Surgery, Brigham and Women’s Hospital
- Philip E. Blazar
- Department of Orthopedic Surgery, Brigham and Women’s Hospital
- John Wright
- Department of Orthopedic Surgery, Brigham and Women’s Hospital
- Barry P. Simmons
- Department of Orthopedic Surgery, Brigham and Women’s Hospital
- Laura T. Donlin
- Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
- George D. Kalliolias
- Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
- Susan M. Goodman
- Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
- Vivian P. Bykerk
- Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
- Lionel B. Ivashkiv
- Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
- James A. Lederer
- Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School
- Nir Hacohen
- Broad Institute of MIT and Harvard
- Peter A. Nigrovic
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Andrew Filer
- Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital
- Christopher D. Buckley
- Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital
- Soumya Raychaudhuri
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Michael B. Brenner
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-018-02892-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Synovial fibroblasts are thought to be central mediators of joint destruction in rheumatoid arthritis (RA). Here the authors use single-cell transcriptomics and flow cytometry to identify synovial fibroblast subsets that are expanded and display distinct tissue distribution and function in patients with RA.
