Gaceta Mexicana de Oncología (Apr 2022)

Prolactin increases cell migration of MCF-7 cells without inducing an epithelium-mesenchyme transition

  • Jesús A. Lara-Reyes,
  • Zuleima H. Castillo-García,
  • Gonzalo E. Aranda-Abreu,
  • Deissy Herrera-Covarrubias,
  • Clara L. Sampieri-Ramírez,
  • Arnoldo Aquino-Gálvez,
  • Jorge M. Suárez-Medellín,
  • Ma. Elena Hernández-Aguilar,
  • Fausto Rojas-Durán

DOI
https://doi.org/10.24875/j.gamo.22000006
Journal volume & issue
Vol. 21, no. 2

Abstract

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Objective: To evaluate the effect of prolactin (PRL) on the migration of MCF-7 breast cancer cells and the expression of E-cadherin. Methods: We used the wound healing assays to evaluate the migration of MCF-7 cells and the Western blot technique to evaluate the expression of E-cadherin. Results: The results show that PRL produced an increase in the migration of MCF-7 cells without inducing a reduction in the expression of E-cadherin. Conclusions: Prolactin significantly increased the migration of MCF-7 breast cancer cell line without inducing an epithelial-mesenchymal transition (EMT), which could be related to a collective type of migration.

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