Label-free imaging for quality control of cardiomyocyte differentiation

Tongcheng Qian; Tiffany M. Heaster; Angela R. Houghtaling; Kexin Sun; Kayvan Samimi; Melissa C. Skala

doi:10.1038/s41467-021-24868-1

Nature Communications (Jul 2021)

Label-free imaging for quality control of cardiomyocyte differentiation

Tongcheng Qian,
Tiffany M. Heaster,
Angela R. Houghtaling,
Kexin Sun,
Kayvan Samimi,
Melissa C. Skala

Affiliations

Tongcheng Qian: Morgridge Institute for Research
Tiffany M. Heaster: Morgridge Institute for Research
Angela R. Houghtaling: Morgridge Institute for Research
Kexin Sun: Morgridge Institute for Research
Kayvan Samimi: Morgridge Institute for Research
Melissa C. Skala: Morgridge Institute for Research

DOI: https://doi.org/10.1038/s41467-021-24868-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Differentiation of hPSCs to cardiomyocytes suffers from high variability. Here the authors report a label-free live cell imaging platform based on autofluorescence imaging to enable the prediction of cardiomyocyte differentiation efficiency from hPSCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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