Acute effect of exercise on appetite‐related factors in males with obesity: A pilot study

Abstract

Abstract To investigate the role of appetite‐related factors, including interleukin 6 (IL‐6), irisin, interleukin 7 (IL‐7), neuropeptide Y (NPY), and leptin, on appetite perception in males with obesity. Eleven males (BMI 35.3 ± 4.2 kg/m2, V̇O2peak 29 ± 3.1 mL/kg/min) participated in two experimental trials (MICE: 60 min of cycling at 60% of V̇O2peak; CTRL: 60 min of quiet resting) using a crossover design. Appetite parameters, including IL‐6, IL‐7, irisin, and leptin, were measured. Additionally, appetite perception was assessed. IL‐6 concentration increased significantly immediately post‐exercise (95% CI: [2.207–12.192] pg/mL, p = 0.007) and remained elevated 1 hour post‐exercise (95% CI: [2.326–11.855] pg/mL, p = 0.006) compared to CTRL. Irisin also rose significantly immediately post‐exercise (95% CI: [0.084–3.061] ng/mL, p = 0.039). NPY decreased significantly 1 h post‐exercise (95% CI: [(−20.601) – (−1.380)] ng/L, p = 0.027). No significant differences were observed for IL‐7 (p = 0.748, ηp2 = 0.077) and leptin (p = 0.285, ηp2=0.061). Appetite perceptions were suppressed immediately post‐exercise (95% CI: [3.407–19.547] mm, p = 0.008) compared to CTRL. Sixty minutes of MICE increased IL‐6 and irisin concentrations while suppressed NPY and appetite perceptions in males with obesity.

Keywords

• appetite perceptions
• appetite‐regulation
• IL‐6
• IL‐7
• irisin
• NPY